{"id":25567,"date":"2023-01-20T16:19:02","date_gmt":"2023-01-20T19:19:02","guid":{"rendered":"https:\/\/medicina.utalca.cl\/?page_id=25567"},"modified":"2023-09-12T13:53:58","modified_gmt":"2023-09-12T16:53:58","slug":"productividad-academica-ernesto-solis","status":"publish","type":"page","link":"https:\/\/medicina.utalca.cl\/?page_id=25567","title":{"rendered":"Productividad Acad\u00e9mica Ernesto Sol\u00eds"},"content":{"rendered":"\t\t
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Ernesto Solis A\u00f1es<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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L\u00edneas de investigaci\u00f3n<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\n\t\t\t\t\tEl envejecimiento acelerado de la poblaci\u00f3n en Chile junto con el aumento en el promedio de su expectativa de vida seg\u00fan cifras del INE, hacen proyectar en los pr\u00f3ximos a\u00f1os un aumento en la prevalencia de enfermedades neurodegenerativas como la enfermedad de Alzheimer, enfermedad de Parkinson y enfermedad de Huntington entre otras, constituy\u00e9ndose \u00e9stas en causas principales de discapacidad entre los adultos mayores seg\u00fan la organizaci\u00f3n mundial de la salud (OMS), por lo que el estudio de las mismas representan un desaf\u00edo para el mejoramiento de la calidad de vida y el descubrimiento de nuevas estrategias terap\u00e9uticas.\n\n<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\n\t\t\t\t\tNuestro grupo se enfoca en la epidemiolog\u00eda, variabilidad cl\u00ednica y gen\u00e9tica, e identificaci\u00f3n de marcadores moleculares para la enfermedad de Huntington (EH) como modelo de estudio de neurodegeneraci\u00f3n, dado que al tiempo que \u00e9sta posee caracter\u00edsticas compartidas con otras enfermedades neurodegenerativas como las enfermedades de Alzheimer y Parkinson, y la Esclerosis lateral amiotr\u00f3fica(ELA); tambi\u00e9n posee otras que le son \u00fanicas y que la hacen id\u00f3nea para lograr una mejor comprensi\u00f3n de los mecanismos fisiopatol\u00f3gicos implicados en la neurodegeneraci\u00f3n, y el dise\u00f1o de estrategias terap\u00e9uticas aplicando los conceptos de medicina de precisi\u00f3n y traslacional. <\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Publicaciones recientes<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tSol\u00eds Anez E, Salles P, Rojas N, Benavides O, Chan\u00e1 Cuevas P. Huntington's disease in Chile: epidemiological and genetic aspects. Neuroepidemiology. 2023 Apr 28. doi: 10.1159\/000528961. Online ahead of print<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tMorales-Mach\u00edn A, Delgado W, Borjas L, M\u00e9ndez K, Zabala W, Sol\u00eds E, Chac\u00edn J, Urdaneta K, Mach\u00edn E. Diagn\u00f3stico Prenatal Molecular de Distrofia Muscular Duchenne. Rev Obstet Ginecol Venez 2017;77(4): 251 - 257Pino-Ram\u00edrez G, Sol\u00eds-A\u00f1ez E. Percepci\u00f3n de enfermedad en personas con Trastornos hereditarios del tejido conectivo. Orbis Revista cient\u00edfica Ciencias Humanas 2018; 39:44-61<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tMiranda LE, Chac\u00edn JA, Ch\u00e1vez C, M\u00e8ndez K, Bracho A, Sol\u00eds A\u00f1ez E, Bender F, Graeft Burin M, Giugliani R. Valores de referencia de \u03b2-Glucosidasa y quitotriosidasa en gotas de sangre seca en lactantes venezolanos. Arch venez Puericul pediatr 2016;79(4):127-131<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tDelgado Luengo W, Fleitas H, Sol\u00eds A\u00f1ez E, Hern\u00e1ndez ML, Morales-Machin A, Delgado Luengo J. S\u00edndrome de PAGOD y anomal\u00edas vasculares \u00bfes un defecto de la angiog\u00e9nesis embrionaria?un nuevo caso y revisi\u00f3n. Invest Clin 2016; 57(4): 388\u2013401 <\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tMach\u00edn-Morales A, Fern\u00e1ndez J, Delgado W, \u00c1lvarez F, Bracho A, Hern\u00e1ndez ML, Sol\u00eds E, M\u00e9ndez K, Borjas L. Identificaci\u00f3n de la mutaci\u00f3n \u2206f508 en afectados con \u00edleo meconial. Revist Obstet Ginecol Venez 2016;76(1):53-59<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tArraiz N, Bermudez V, Rondon N, Reyes F, Borjas L, Sol\u00eds E, Mujica E, Prieto C, Reyna N, Velasco M. Novel Mutations Identification in Exon 4 of LDLR Gene in Patients With Moderate Hypercholesterolemia in a Venezuelan Population. Am J Ther. 2010;17:325-329<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tDelgadoW,Petty E,Solis-A\u00f1ez E, Romel O, Delgado Juana, Hern\u00e1ndez Mar\u00eda, Morales-Mach\u00edn A, Borjas L, Zabala W, Gonz\u00e1lez S. Pineda L. Pardo T. Mart\u00ednez M. Gonz\u00e1lez. Urdaneta K. Ca\u00f1izales, J, Fleitas H. Petty-Laxova-Wiedemann Progeroid Syndrome: Further phenotypical delineation and confirmation of a rare syndrome of premature aging. Am J Med Genet A. 2009;149A(10):2200-2205<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tPardo T, Solis E. Aspectos Inmunogen\u00e9ticos del autismo. Revisi\u00f3n..Invest Clin. 2009;50(3):393-406<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tSol\u00eds-A\u00f1ez E, Delgado Luengo W, Hern\u00e1ndez ML.Autismo, cromosoma 15 y la hip\u00f3tesis de disfunci\u00f3n GABA\u00e9rgica..Invest Clin 2007 48;4:529-541<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tSol\u00eds A\u00f1ez E, Delgado Luengo W, Borjas Fuentes L, Zabala W, Arr\u00e1iz N, Pineda L, Portillo MG, Gonz\u00e1lez Ferrer S, Chac\u00edn JA, Pe\u00f1a J, Montiel C, Morales-Mach\u00edn A, Rojas-Atencio A, Ca\u00f1izales J, Gonz\u00e1lez R, Miranda LE, Abreu N, Delgado J. An\u00e1lisis molecular del gen GABRB3 en pacientes con autismo: Estudio exploratorio. Invest Clin 2007 48;2:135-272<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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    Participaci\u00f3n en Proyectos<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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    • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tENROLL-HD: A PROSPECTIVE REGISTRY STUDY IN A GLOBAL HUNTINGTON\u2019S DISEASE. CARGO: COINVESTIGADOR SITE CHILE. INVESTIGADOR \u00a8PRINCIPAL: PEDRO CHANA.2017-2021<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
    • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tA RANDOMIZED, MULTICENTER, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE III CLINICAL STUDY TO EVALUATE THE EFFICACY AND SAFETY OF INTRATHECALLY ADMINISTERED RO7234292 (RG6042) IN PATIENTS WITH MANIFEST HUNTINGTON'S DISEASE. CARGO: SUBINVESTIGADOR. SITE CHILE. INVESTIGADOR PRINCIPAL: PEDRO CHANA.2019-2021<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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      <\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

      Ernesto Solis A\u00f1es L\u00edneas de investigaci\u00f3n El envejecimiento acelerado de la poblaci\u00f3n en Chile junto con el aumento en el promedio de su expectativa de vida seg\u00fan cifras del INE, hacen proyectar en los pr\u00f3ximos a\u00f1os un aumento en la prevalencia de enfermedades neurodegenerativas como la enfermedad de Alzheimer, enfermedad de Parkinson y enfermedad de […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-25567","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=\/wp\/v2\/pages\/25567","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25567"}],"version-history":[{"count":15,"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=\/wp\/v2\/pages\/25567\/revisions"}],"predecessor-version":[{"id":26131,"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=\/wp\/v2\/pages\/25567\/revisions\/26131"}],"wp:attachment":[{"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25567"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}