{"id":25963,"date":"2023-08-11T11:09:15","date_gmt":"2023-08-11T14:09:15","guid":{"rendered":"https:\/\/medicina.utalca.cl\/?page_id=25963"},"modified":"2023-09-12T14:01:01","modified_gmt":"2023-09-12T17:01:01","slug":"productividad-academica-leandro-zuniga","status":"publish","type":"page","link":"https:\/\/medicina.utalca.cl\/?page_id=25963","title":{"rendered":"Productividad Acad\u00e9mica Leandro Z\u00fa\u00f1iga"},"content":{"rendered":"\t\t
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Leandro Z\u00fa\u00f1iga<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\n\t\t\t\t\tScopus ID: 8108125700<\/a><\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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L\u00edneas de investigaci\u00f3n<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tEstructura y funci\u00f3n fisiol\u00f3gica celular de canales i\u00f3nicos<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tEstudios biof\u00edsicos de los canales i\u00f3nicos<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tRol de canales i\u00f3nicos en c\u00e1ncer y dolor<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tB\u00fasqueda y validaci\u00f3n de nuevos agentes farmacol\u00f3gicos asociados a canales i\u00f3nicos<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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    Publicaciones recientes<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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    • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tArevalo B, Bedoya M, Kiper AK, Vergara F, Ramirez D, Mazola Y, Bustos D, Zuniga R, Cikutovic R, Cayo A, Rinne S, Ramirez-Apan MT, Sepulveda FV, Cerda O, Lopez-Collazo E, Decher N, Zuniga L, Gutierrez M, Gonzalez W. Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability. J Med Chem. 2022;65(22):15014-15027<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
    • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tZuniga L, Cayo A, Gonzalez W, Vilos C, Zuniga R. Potassium Channels as a Target for Cancer Therapy: Current Perspectives. Onco Targets Ther. 2022;15:783-797<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
    • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tZuniga R, Mancilla D, Rojas T, Vergara F, Gonzalez W, Catalan MA, Zuniga L. A Direct Interaction between Cyclodextrins and TASK Channels Decreases the Leak Current in Cerebellar Granule Neurons. Biology (Basel). 2022;11(8)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
    • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tMazola Y, Marquez Montesinos JCE, Ramirez D, Zuniga L, Decher N, Ravens U, Yarov-Yarovoy V, Gonzalez W. Common Structural Pattern for Flecainide Binding in Atrial-Selective K(v)1.5 and Na(v)1.5 Channels: A Computational Approach. Pharmaceutics. 2022;14(7)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
    • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tMunoz-Quezada MT, Lucero B, Castillo B, Bradman A, Zuniga L, Baumert BO, Iglesias V, Munoz MP, Buralli RJ, Antini C. Psychometric Validation of a Questionnaire to Assess Perception and Knowledge About Exposure to Pesticides in Rural Schoolchildren of Maule, Chile. Front Psychol. 2021;12:715477<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
    • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tElemento de listaZuniga R, Concha G, Cayo A, Cikutovic-Molina R, Arevalo B, Gonzalez W, Catalan MA, Zuniga L. Withaferin A suppresses breast cancer cell proliferation by inhibition of the two-pore domain potassium (K2P9) channel TASK-3. Biomed Pharmacother. 2020;129:110383<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
    • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tBustos D, Bedoya M, Ramirez D, Concha G, Zuniga L, Decher N, Hernandez-Rodriguez EW, Sepulveda FV, Martinez L, Gonzalez W. Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K(2)P Channels. Int J Mol Sci. 2020;21(2)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
    • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tCikutovic-Molina R, Herrada AA, Gonzalez W, Brown N, Zuniga L. TASK-3 Gene Knockdown Dampens Invasion and Migration and Promotes Apoptosis in KATO III and MKN-45 Human Gastric Adenocarcinoma Cell Lines. Int J Mol Sci. 2019;20(23)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
    • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tConcha G, Bustos D, Zuniga R, Catalan MA, Zuniga L. Correction: Concha, G., et al. The Insensitivity of TASK-3 K(2)P Channels to External Tetraethylammonium (TEA) Partially Depends on the Cap Structure. Int. J. Mol. Sci. 2018, 19, 2437. Int J Mol Sci. 2019;20(18)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
    • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tRamirez D, Concha G, Arevalo B, Prent-Penaloza L, Zuniga L, Kiper AK, Rinne S, Reyes-Parada M, Decher N, Gonzalez W, Caballero J. Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening. Int J Mol Sci. 2019;20(16)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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      Participaci\u00f3n en Proyectos Vigentes<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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      • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tFONDECYT 1230996: MULTIDISCIPLINARY GENERATION OF HIGHLY SPECIFIC PEPTIDIC BLOCKERS OF TASK-3 CHANNEL WITH ANTITUMORAL EFFECT AND TARGETING MOIETY FOR NANOTHERAPEUTICS (2023-2027). Funci\u00f3n: Investigador Principal (PI)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
      • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tFONDECYT 1230446: LIGAND AND STRUCTURE-BASED POLYPHARMACOLOGY OF K+ CHANNELS FROM THE PRIMARY SENSORY NEURONS (2023-2027). Funci\u00f3n: Co-Investigador (Co-I); PI Wendy Gonz\u00e1lez.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
      • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tFIC-R: PORTAFOLIO DE SERVICIOS PARA LA CARACTERIZACI\u00d3N DE BLANCOS TERAP\u00c9UTICOS PARA EL TRATAMIENTO DE C\u00c1NCER Y ENFERMEDADES CR\u00d3NICAS NO TRANSMISIBLES (2021-2023).Funci\u00f3n: Co-Investigador (Co-I); PI Wendy Gonz\u00e1lez.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

        Leandro Z\u00fa\u00f1iga Scopus ID: 8108125700 L\u00edneas de investigaci\u00f3n Estructura y funci\u00f3n fisiol\u00f3gica celular de canales i\u00f3nicos Estudios biof\u00edsicos de los canales i\u00f3nicos Rol de canales i\u00f3nicos en c\u00e1ncer y dolor B\u00fasqueda y validaci\u00f3n de nuevos agentes farmacol\u00f3gicos asociados a canales i\u00f3nicos Publicaciones recientes Arevalo B, Bedoya M, Kiper AK, Vergara F, Ramirez D, Mazola Y, […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-25963","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=\/wp\/v2\/pages\/25963","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25963"}],"version-history":[{"count":16,"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=\/wp\/v2\/pages\/25963\/revisions"}],"predecessor-version":[{"id":26142,"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=\/wp\/v2\/pages\/25963\/revisions\/26142"}],"wp:attachment":[{"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25963"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}