{"id":25971,"date":"2023-08-11T11:26:10","date_gmt":"2023-08-11T14:26:10","guid":{"rendered":"https:\/\/medicina.utalca.cl\/?page_id=25971"},"modified":"2023-09-12T14:34:57","modified_gmt":"2023-09-12T17:34:57","slug":"productividad-academica-nelson-brown","status":"publish","type":"page","link":"https:\/\/medicina.utalca.cl\/?page_id=25971","title":{"rendered":"Productividad Acad\u00e9mica Nelson Brown"},"content":{"rendered":"\t\t
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Nelson Brown<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\n\t\t\t\t\tScopus ID: 7403548076<\/a><\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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L\u00edneas de investigaci\u00f3n<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\n\t\t\t\t\tRol de ciclina D1 en tumorig\u00e9nesis: inicialmente, nuestro trabajo consisti\u00f3 examinar el rol de la prote\u00edna ciclina D1 \u2013 un regulador de la progresi\u00f3n del ciclo celular que participa en la activaci\u00f3n de las quinasas dependientes de ciclina 4 y 6 (CDK4\/6) \u2013 en el desarrollo de tumores mamarios en el rat\u00f3n. Trabajos anteriores hab\u00edan demostrado que la introducci\u00f3n de una mutaci\u00f3n puntual en el gen que codifica para ciclina D1 en ratones era capaz de prevenir por completo el desarrollo de c\u00e1ncer mamario asociado a la activaci\u00f3n del receptor tiros\u00edn-kinasa HER-2, fenocopiando as\u00ed la acci\u00f3n de inhibidores de CDK4\/6. Utilizando este modelo, pudimos demostrar que esta mutaci\u00f3n altera la capacidad de divisi\u00f3n de las c\u00e9lulas epiteliales progenitoras en el tejido mamario.<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\n\t\t\t\t\tInhibidores de CDK4\/6 en senescencia y autofagia: m\u00e1s recientemente, nuestro laboratorio se ha focalizado en examinar el rol de los complejos ciclina D1-CDK4\/6 en senescencia celular y autofagia, dos procesos frecuentemente alterados en c\u00e1ncer. Parte de este trabajo se ha centrado en caracterizar el fenotipo senescente de c\u00e9lulas tumorales tratadas con inhibidores de CDK4\/6 (y otras drogas antitumorales), particularmente el efecto que tiene el secretoma de las c\u00e9lulas senescentes en la progresi\u00f3n tumoral, la activaci\u00f3n plaquetaria, as\u00ed como la activaci\u00f3n de componentes celulares del sistema inmune, utilizando para ello modelos in vitro de c\u00e1ncer mamario y g\u00e1strico. Este trabajo ha llevado al reconocimiento de que ciertos factores solubles liberados por las c\u00e9lulas tumorales senescentes pueden promover la migraci\u00f3n y la invasi\u00f3n de c\u00e9lulas tumorales no senescentes (en activa proliferaci\u00f3n), as\u00ed como la activaci\u00f3n y agregaci\u00f3n de las plaquetas. Estos efectos podr\u00edan ayudar a explicar la eventual recurrencia del tumor, as\u00ed como los fen\u00f3menos tromb\u00f3ticos, frecuentemente observados en pacientes sometidos a tratamientos con drogas antitumorales inductoras de senescencia celular.<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Publicaciones recientes<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tCayo A, Venturini W, Rebolledo-Mira D, Moore-Carrasco R, Herrada AA, Nova-Lamperti E, Valenzuela C, Brown NE. Palbociclib-Induced Cellular Senescence Is Modulated by the mTOR Complex 1 and Autophagy. Int J Mol Sci. 2023;24(11)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tHuilcaman R, Venturini W, Fuenzalida L, Cayo A, Segovia R, Valenzuela C, Brown N, Moore-Carrasco R. Platelets, a Key Cell in Inflammation and Atherosclerosis Progression. Cells. 2022;11(6)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\taldes F, Arevalo B, Gutierrez M, Garcia-Castillo V, Salgado-Garcia R, Perez-Plasencia C, Valenzuela C, Cayo A, Olate-Briones A, Brown N. Two New Adenosine Derivatives and their Antiproliferative Properties: An In Vitro Evaluation. Anticancer Agents Med Chem. 2022;22(7):1414-1425<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tVenturini W, Olate-Briones A, Valenzuela C, Mendez D, Fuentes E, Cayo A, Mancilla D, Segovia R, Brown NE, Moore-Carrasco R. Platelet Activation Is Triggered by Factors Secreted by Senescent Endothelial HMEC-1 Cells In Vitro. Int J Mol Sci. 2020;21(9)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tCikutovic-Molina R, Herrada AA, Gonzalez W, Brown N, Zuniga L. TASK-3 Gene Knockdown Dampens Invasion and Migration and Promotes Apoptosis in KATO III and MKN-45 Human Gastric Adenocarcinoma Cell Lines. Int J Mol Sci. 2019;20(23)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tValenzuela CA, Quintanilla R, Olate-Briones A, Venturini W, Mancilla D, Cayo A, Moore-Carrasco R, Brown NE. SASP-Dependent Interactions between Senescent Cells and Platelets Modulate Migration and Invasion of Cancer Cells. Int J Mol Sci. 2019;20(21)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tValdes F, Brown N, Morales-Bayuelo A, Prent-Penaloza L, Gutierrez M. Adenosine Derivates as Antioxidant Agents: Synthesis, Characterization, in Vitro Activity, and Theoretical Insights. Antioxidants (Basel). 2019;8(10)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tZuniga R, Valenzuela C, Concha G, Brown N, Zuniga L. TASK-3 Downregulation Triggers Cellular Senescence and Growth Inhibition in Breast Cancer Cell Lines. Int J Mol Sci. 2018;19(4)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tZuniga R, Gonzalez D, Valenzuela C, Brown N, Zuniga L. Expression and cellular localization of HCN channels in rat cerebellar granule neurons. Biochem Biophys Res Commun. 2016;478(3):1429-1435<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\tEchiburu-Chau C, Alfaro-Lira S, Brown N, Salas CO, Cuellar M, Santander J, Ogalde JP, Rothhammer F. The selective cytotoxicity elicited by phytochemical extract from Senecio graveolens (Asteraceae) on breast cancer cells is enhanced by hypoxia. Int J Oncol. 2014;44(4):1357-1364<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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    Participaci\u00f3n en Proyectos Vigente<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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    • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t2021-presente: FONDECYT DE INICIO (Co-investigador). T\u00edtulo del proyecto: \u201cThe role of autophagy in the modulation of the secretome of gastric cancer cells undergoing senescence\u201d<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
    • \n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t<\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t2020-presente: FONDECYT REGULAR (Co-investigador). T\u00edtulo del proyecto: \u201cDual inhibition of the mammalian target of rapamycin (mTOR) and the extracellular signal-regulated kinases (ERKs) induce a synergistic effect of chemotherapeutic drugs on colorectal cancer\u201d<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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      <\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

      Nelson Brown Scopus ID: 7403548076 L\u00edneas de investigaci\u00f3n Rol de ciclina D1 en tumorig\u00e9nesis: inicialmente, nuestro trabajo consisti\u00f3 examinar el rol de la prote\u00edna ciclina D1 \u2013 un regulador de la progresi\u00f3n del ciclo celular que participa en la activaci\u00f3n de las quinasas dependientes de ciclina 4 y 6 (CDK4\/6) \u2013 en el desarrollo de […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-25971","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=\/wp\/v2\/pages\/25971","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25971"}],"version-history":[{"count":13,"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=\/wp\/v2\/pages\/25971\/revisions"}],"predecessor-version":[{"id":26149,"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=\/wp\/v2\/pages\/25971\/revisions\/26149"}],"wp:attachment":[{"href":"https:\/\/medicina.utalca.cl\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25971"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}