Leandro Zúñiga
Líneas de investigación
- Estructura y función fisiológica celular de canales iónicos
- Estudios biofísicos de los canales iónicos
- Rol de canales iónicos en cáncer y dolor
- Búsqueda y validación de nuevos agentes farmacológicos asociados a canales iónicos
Publicaciones recientes
- Arevalo B, Bedoya M, Kiper AK, Vergara F, Ramirez D, Mazola Y, Bustos D, Zuniga R, Cikutovic R, Cayo A, Rinne S, Ramirez-Apan MT, Sepulveda FV, Cerda O, Lopez-Collazo E, Decher N, Zuniga L, Gutierrez M, Gonzalez W. Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability. J Med Chem. 2022;65(22):15014-15027
- Zuniga L, Cayo A, Gonzalez W, Vilos C, Zuniga R. Potassium Channels as a Target for Cancer Therapy: Current Perspectives. Onco Targets Ther. 2022;15:783-797
- Zuniga R, Mancilla D, Rojas T, Vergara F, Gonzalez W, Catalan MA, Zuniga L. A Direct Interaction between Cyclodextrins and TASK Channels Decreases the Leak Current in Cerebellar Granule Neurons. Biology (Basel). 2022;11(8)
- Mazola Y, Marquez Montesinos JCE, Ramirez D, Zuniga L, Decher N, Ravens U, Yarov-Yarovoy V, Gonzalez W. Common Structural Pattern for Flecainide Binding in Atrial-Selective K(v)1.5 and Na(v)1.5 Channels: A Computational Approach. Pharmaceutics. 2022;14(7)
- Munoz-Quezada MT, Lucero B, Castillo B, Bradman A, Zuniga L, Baumert BO, Iglesias V, Munoz MP, Buralli RJ, Antini C. Psychometric Validation of a Questionnaire to Assess Perception and Knowledge About Exposure to Pesticides in Rural Schoolchildren of Maule, Chile. Front Psychol. 2021;12:715477
- Elemento de listaZuniga R, Concha G, Cayo A, Cikutovic-Molina R, Arevalo B, Gonzalez W, Catalan MA, Zuniga L. Withaferin A suppresses breast cancer cell proliferation by inhibition of the two-pore domain potassium (K2P9) channel TASK-3. Biomed Pharmacother. 2020;129:110383
- Bustos D, Bedoya M, Ramirez D, Concha G, Zuniga L, Decher N, Hernandez-Rodriguez EW, Sepulveda FV, Martinez L, Gonzalez W. Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K(2)P Channels. Int J Mol Sci. 2020;21(2)
- Cikutovic-Molina R, Herrada AA, Gonzalez W, Brown N, Zuniga L. TASK-3 Gene Knockdown Dampens Invasion and Migration and Promotes Apoptosis in KATO III and MKN-45 Human Gastric Adenocarcinoma Cell Lines. Int J Mol Sci. 2019;20(23)
- Concha G, Bustos D, Zuniga R, Catalan MA, Zuniga L. Correction: Concha, G., et al. The Insensitivity of TASK-3 K(2)P Channels to External Tetraethylammonium (TEA) Partially Depends on the Cap Structure. Int. J. Mol. Sci. 2018, 19, 2437. Int J Mol Sci. 2019;20(18)
- Ramirez D, Concha G, Arevalo B, Prent-Penaloza L, Zuniga L, Kiper AK, Rinne S, Reyes-Parada M, Decher N, Gonzalez W, Caballero J. Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening. Int J Mol Sci. 2019;20(16)
Participación en Proyectos Vigentes
- FONDECYT 1230996: MULTIDISCIPLINARY GENERATION OF HIGHLY SPECIFIC PEPTIDIC BLOCKERS OF TASK-3 CHANNEL WITH ANTITUMORAL EFFECT AND TARGETING MOIETY FOR NANOTHERAPEUTICS (2023-2027). Función: Investigador Principal (PI)
- FONDECYT 1230446: LIGAND AND STRUCTURE-BASED POLYPHARMACOLOGY OF K+ CHANNELS FROM THE PRIMARY SENSORY NEURONS (2023-2027). Función: Co-Investigador (Co-I); PI Wendy González.
- FIC-R: PORTAFOLIO DE SERVICIOS PARA LA CARACTERIZACIÓN DE BLANCOS TERAPÉUTICOS PARA EL TRATAMIENTO DE CÁNCER Y ENFERMEDADES CRÓNICAS NO TRANSMISIBLES (2021-2023).Función: Co-Investigador (Co-I); PI Wendy González.